Possible Interaction: Androstenedione and Ketoconazole

“Conclusions: Higher androstenedione levels predict likelihood of response to ketoconazole and improved survival compared with patients with lower levels.”

“Flutamide, ketoconazole , and EE-CPA induced a significant decrease in total and free testosterone, 5alpha-dihydrotestosterone, dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione plasma levels.”

“The adrenal androgens, Δ(4)-androstene-3,17-dione , dehydroepiandrosterone and dehydroepiandrosterone sulfate were significantly reduced in the patients receiving ketoconazole or AA compared to those who did not.”

“The same low-dose ketoconazole , administered to PCOS women, decreased serum values of androstenedione (17.6% +/- 4.7%), T (24.6% +/- 7.6%), and free T (30.7% +/- 7.7%).”

“This indicates a strong inhibition of ovarian C17,20-desmolase by ketoconazole … concentration (IC50) of 23 microM. After incubation of human granulosa cells with ketoconazole (… [3H]androstenedione the production of [3H]estrone and [3H]estradiol was suppressed to … 35% of basal values, indicating a significant inhibition of ovarian aromatase.”

“Results When applied shortly before gonadotropin stimulation, KCZ markedly reduced ovarian progesterone, androstenedione , and estradiol levels down to 18.7, 36.5, and 19.0%, respectively (P < 0.001).”