Possible Interaction: Androstenedione and Hydrocortisone

“The addition of hydrocortisone resulted in further reductions of androstenedione and testosterone levels in males.”

“When comparing the areas under response curves (AUCs), the correlation of ASD and CORT was significantly negative in RA (p = 0.009), but positive in controls (RA vs control difference in Spearman's correlations, p = 0.002).”

“Our data show that androstenedione synthesis is inversely related to the synthesis of cortisol and cortisone.”

“In contrast to conventional dose AG with hydrocortisone , or low dose AG without hydrocortisone, delta 4 androstenedione was suppressed by 65%.”

“During combined treatment with 500–1000 mg/d of AG and cortisol 40 mg/d, AN and TS were significantly higher than during treatment with cortisol alone, suggesting that cortisol had not completely blocked ACTH secretion.”

“Comparisons of the changes in cortisol, testosterone and androstenedione in relation to the control level show that significant correlations existed between the percentage increases in cortisol and androstenedione , and between the percentage decrease in testosterone and percentage increase in androstenedione.”

“ cortisol is reversed by physiological concentrations of many of the commercially-available androgenic steroids, including testosterone, dihydroxy-testosterone, androstenedione , and dehydroepiandrosterone sulphate.”

“ cortisol is reversed by physiological concentrations of many of the commercially-available androgenic steroids, including testosterone, dihydroxy-testosterone, androstenedione , and dehydroepiandrosterone sulphate.”

“In thecal cells, doses of 1–100 ng/mL of cortisol increased (p<0.05) insulin- and IGF-1-induced thecal cell numbers by 10–20%, progesterone production by 18–36%, and androstenedione production by two- to fourfold.”

“Baseline cortisol concentrations were significantly correlated with progesterone, 17-hydroxyprogesterone (17-OHP) and androstenedione.”