Possible Interaction: Androstenedione and Gonadotropin-Releasing Hormone

“Serum total testosterone, free testosterone, androstenedion and DHEA-S showed a meaningful decrease in patients treated with GnRH agonist.”

“Serum and IT ADD and IT DHEA are markedly suppressed with GnRH administration and stimulated by hCG, but serum DHEA is not, suggesting that most circulating DHEA is not of testicular origin.”

“We hypothesized that serum and IT androstenedione ADD ) and IT dehydroepiandrosterone (DHEA) would be significantly suppressed by the administration of a GnRH antagonist and increased when stimulated by hCG, without a similar suppression of serum DHEA.”

“The content of the steroid hormones dihydroepiandrosterone sulfate (DHEA)-S, testosterone, androstenedione , oestradiol, progesterone and 17-alpha-hydroxyprogesterone/g testicular tissue was significantly lower in patients on LHRH agonists.”

“The adrenal hormone secretion (DHEA, DHEAS) remained unaffected, whereas the androgens of ovarian origin (testosterone, androstendione ) were suppressed during the GnRH analogue treatment.”

“In the bats treated with hCG, PMSG and GnRH agonist, androstenedione concentration increased significantly to extraordinarily high levels, whereas estradiol concentration decreased.”

“Follicular fluid (FFL) concentrations of estradiol (P < 0.01) and androstenedione (P < 0.05) were greater in GnRH vs control cows.”

“Serum levels of dehydroepiandrosterone, androst-5-ene-3 beta,17 beta-diol, androstenedione and androstane-3 alpha, 17 beta-diol were 75 to 95% inhibited by the LHRH agonist while serum testosterone and dihydrotestosterone concentrations were reduced below detection limits by the same treatment.”

“… GnRH agonist treatment, plasma steroid levels, namely …-3 beta-17 beta-diol, androstenedione , testosterone, dihydrotestosterone, 5 alpha-androstane-3 alpha, 17 beta-diol, 5 alpha-androstane, 3 beta, 17 beta-diol … in male animals, whereas in female animals, the plasma concentration of DHEA and delta 5-diol were decreased.”

“The plasma concentration of androstenedione was raised by GnRF to a greater extent during anoestrus than during oestrus.”

“Measurement of prostatic steroid content … that administration of the LHRH agonist as well as castration … with a marked decrease in androstenedione , testosterone, and dihydrotestosterone levels in prostate while there is a small inhibition of androst‐…‐3β,17β‐diol, androstane‐3β,17β‐diol, dehydroepiandrosterone, and estrone concentrations in this tissue.”