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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Androstenedione
drug:
Estrone
Research Papers that Mention the Interaction
“We concluded that the acute administration of both 50-mg and 100-mg of androstenedione increases serum testosterone and estrone levels, but not estradiol levels, in postmenopausal women.”
Effects of oral androstenedione administration on serum testosterone and estradiol levels in postmenopausal women.“A positive relation existed between the levels of androstenedione and estrone , which shows that suppression of these adrenal androgens may result in suppression of plasma estrone.”
“ Estrone correlated linearly with androstenedione (r=0.28, p<0.001) but there was no correlation between estradiol and testosterone.”
“Approximately 100 ng of strone is produced daily by aromatization of androstenedione , which esults in a plasma estradiol level of between 10 and 20 pg/mL.”
“Biochemical studies suggest that the mechanism of action may be inhibition of conversion of androstenedione to oestrone.”
“ Estrone was also positively related to androstenedione concentrations (r = 0.33, p less than 0.001).”
“After the first post-menopausal year a significant positive correlation was found between the levels of oestrone and androstenedione.”
“The conversion ratio of androstenedione to estrone , estradiol and testosterone and the conversion ratio of testosterone to estrone (but not estradiol) and androstenedione were significantly increased.”
“The conversion ratio of androstenedione to estrone was significantly increased in both males and females (0.0396 and 0.0256, respectively).”
“There was a significantly greater percentage of conversion of androstenedione to estrone as compared to that found in healthy postmenopausal women in the control study.”
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