Possible Interaction: Androstenedione and Estradiol

“At all times during the stimulation period a significant correlation between estradiol and testosterone or androstenedione levels was observed.”

“These results indicate that repeated long-term injections of androstenedione or DHT and estradiol induced stromal hyperplasia, which may be an estrogen-related effect.”

“Testosterone and androstenedione competitively inhibited estradiol 2-hydroxylation, and estrone and estradiol competitively inhibited aromatization of both testosterone and androstenedione.”

“Consumption of SPI- significantly increased estradiol and androstenedione concentrations, and tended to suppress AR expression (P = 0.09).”

“Similarly, in the presence of androstenedione, estradiol production was enhanced by activin A but decreased by follistatin-288.”

“Here we provide evidence showing that a non-genomic effect of oestradiol is counteracted by androstenedione.”

“Cells were cultured … days and basal oestradiol (nmol/l) fell dramatically over … the presence and absence of androtenedione , e.g. from 339 (223-419) (median and interquartile range, cells from five patients cultured in …) after 2 days to 14 (7-59) after 6 days.(ABSTRACT TRUNCATED AT 250 WORDS)”

“A severalfold increase in estradiol production from androstenedione was induced by both hormones in these cells, while only FSH led to a concomitant increase in cAMP.”

“In groups IV and V, progesterone increased (p less than 0.05) 1 day after human chorionic gonadotropin and remained elevated for 5 to 6 days; a 4-day rise (p less than 0.05) in estradiol began 3 days after treatment, and androstenedione rose modestly in parallel.”

“Throughout puberty, ratios of delta 4-androstenedione to estrone (E1) and estradiol (E2) were significantly lower in the gynecomastia group than in the control group.”