Possible Interaction: Androstenedione and Dihydrotestosterone

“… DHT ) concentrations …- (for androstenedione and DHT, respectively, 10.4 ± 0.6 nmol/L and 2198.2 ± 166.5 pmol/L) than in the 40- (6.8 ± 0.….8 ± 152.0 pmol/L) or 50 year olds (6.0 ± 0.7 nmol/L and 1983.7 ± 147.8 pmol/L).”

“We conclude that the administration of both 100 and 300 mg androstenedione increases the excretion rates of conjugated testosterone, androsterone, etiocholanolone, and dihydrotestosterone and the serum levels of testosterone glucuronide in men.”

“Furthermore, 5α-reduction of AD was the major directionality of metabolic flux to DHT.”

“However, the presence of various steroidogenic enzymes in the prostate as well as the availability at high levels of various steroid precursors such as dehydroepiandrosterone sulphate (DHEAS), dehydroepiandrosterone (DHEA) and 4-androstenedione (4-dione) strongly suggest the existence of additional pathways involved in the biosynthesis and metabolism of DHT.”

“Yields of 4-androstenedione showed an inverse relationship to those of DHT , in response to the agents tested, in keeping with the 17-beta hydroxysteroid dehydrogenase pathway.”

“ DHT markedly decreased Vg and E2 levels, suggesting that DHEA and androstenedione increased Vg and E2 via conversion to E2 and not by estrogen receptor agonism.”

“In both tumor-free and GC tumor host mice, dietary or capsular treatment with DHEA, TESTO, or DHT resulted in substantial alteration in one or more of serum steroids, DHEA, androstenedione , TESTO, and DHT, in addition to the administered steroid.”

“Immunization against dihydrotestosterone and androstenedione yielded equivocal results because of high cross reaction of the respective antisera with other androgens.”