Possible Interaction: Androstenedione and Dexamethasone

“In groups 2 and 3, DHEAS levels were significantly higher, suppression of androstenedione by dexamethasone was significantly greater, and ovulation rates with clomiphene citrate were significantly lower than in group 1.”

“DHEA-S and androstenedione significantly decreased in the DO, DM , and DOM groups after treatment.”

“We found elevated serum 17-hydroxyprogesterone (17-OHP) and androstenedione that were suppressed with dexamethasone , and elevated testosterone that actually rose after giving dexamethasone, indicating activity of the hypothalamic-pituitary-gonadal (HPG) axis.”

“Our patient demonstrated only partial suppression of androstenedione and testosterone following dexamethasone administration.”

“ Dexamethasone screening test decreases dehydroepioandrosterone sulfate and androstenedion , whereas testosterone levels are only partly suppressed.”

“Serum DHEAS, androstenedione , and testosterone suppressed following dexamethasone suppression (n = 16), thereby distinguishing adrenarche patients from adrenal tumour patients.”

“On investigation, she had elevated testosterone, androstenedione , dihydroepiandrosterone sulphate and 17α‐hydroxyprogesterone levels, which were all suppressed by overnight dexamethasone to within their normal ranges.”

“After 2 mg dexamethasone for 3 days (n = 10), 11 beta-hydroxyandrostenedione, dehydroepiandrosterone sulfate, androstenedione , and testosterone were suppressed by 95% +/- 2%, 74% +/- 3%, 51% +/- 9%, and 32% +/- 9%, respectively.”

“ Dexamethasone induced only a minute decrease in the delta 4-progestagens, a marked decrease in pregnenolone, with a more than 80% reduction of 17 alpha- hydroxypregnenolone, dehydroepiandrosterone, dehydroepiandrosterone sulfate and androstenedione.”

“Treatment with dexamethasone significantly reduced plasma values of testosterone, DHA-S, androstenedione (adione), cortisol and the LH/FSH ratio (basal and after GnRH), but adrenal hyperresponsiveness to ACTH was maintained.”