Possible Interaction: Androstenedione and Dehydroepiandrosterone

“RESULTS In all treated women, DH A si gnificantly increased serum DHEAS, and rostenedione an d testosterone concentrations.”

“ DHEA replacement significantly increased DHEA-S (sulfated ester of DHEA), bioavailable testosterone, and androstenedione and reduced sex hormone-binding globulin levels.”

“The administration of DHEA raised the serum levels of DHEAS to normal age-related reference ranges and increased androstenedione and T to subnormal levels.”

“… DHEA increased rapidly and reached a maximum at 180-240 min, … +/- 1.6 to 28.2 +/- 4.6 mumol/L) and androstenedione (1.4 +/- 0.3 to 19.5 +/- 9.8 nmol/L), 2.5-fold … nmol/L), but estrone, estradiol, and sex hormone-binding globulin (SHBG) were unchanged.”

“The LC-MS/MS analysis revealed that, in hvSMCs, short term DHEA supplementation increased Δ4-androstenedione levels in spent medium, while increasing testosterone (T) and dihydrotestosterone (DHT) secretion after longer incubation.”

“Adjuvant treatment with DHEA boosted the serum concentration of a number of androgen-related analytes, including total and free testosterone, androstenedione , and DHEAS, while serum SHBG remained unchanged.”

“ Dehydroepiandrotone (DHEA) to androstenedione ratio had 6 fold increases.”

“The correlation between AUCs of ASD and DHEA was strongly positive in controls (p = 0.006), but not in RA (RA vs. control difference p = 0.044).”

“ Dehydroepiandrosterone in relation to androstenedione or cortisol was increased.”

“The daily administration of 50 mg of DHEA to women over 60 years old results in a two-fold increase in serum level of testosterone and androstenedione and in a 10% increase of estradiol in men.”