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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Androstenedione
drug:
Colforsin
Research Papers that Mention the Interaction
“In the presence of forskolin , HOTT cell production of androstenedione , 17OHP, and progesterone increased by approximately 4.5-, 35-, and 3-fold, respectively.”
Bone morphogenetic protein inhibits ovarian androgen production.“Treatment of monolayer cultures of HOTT cells with forskolin (0.01 to 20 mumol/L) or dbcAMP (0.01 to 1 mmol/L) for 48 h increased the production of androstenedione (8- to 15-fold) and progesterone (2- to 5-fold).”
“ Androstenedione accumulation was decreased by 60% in the forskolin plus activin group compared with forskolin alone, while progesterone production was maintained.”
“ Forskolin (10 microM) markedly increased production of both androstenedione (fivefold) and progesterone (threefold) as well as the activity of 3 beta HSD (sevenfold), and P450c17 (sevenfold) over basal.”
“In contrast, co-treatment with forskolin and inhibin increased androstenedione production by 40% while decreasing progesterone by 40% compared with forskolin alone.”
“ Forskolin and dibutyryl cAMP, which were more effective than ACTH, enhanced the production of DHEA and androstenedione over a 48-hour treatment period.”
“ Forskolin treatment increased androstenedione (fivefold), DHEA (tenfold), and 17OHP (40-fold) compared with basal levels.”
“In the presence of forskolin , GA and HA treatment further increased androstenedione secretion.”
Src tyrosine kinase regulates CYP17 expression and androstenedione secretion in theca-enriched mouse ovarian cells“Treatment of thecal cells with cholera toxin (0.001-100 ng/tube) or forskolin (0.001-10 microM) resulted in a dose-dependent increase in cellular cAMP levels and androstenedione secretion.”
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