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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Androstenedione
drug:
Carbon Monoxide
Research Papers that Mention the Interaction
“These observations suggested that the aromatization of androst-4-en-3,17-dione should be inhibited by carbon monoxide if sufficient concentrations of the 19-nor steroids were present in reaction flasks.”
Differential inhibition of androst-4-en-3,17-dione aromatization by carbon monoxide in the presence of estr-4-en-3,17-dione“Serum Co concentrations increased over time in horses consuming both ADD (P = 0.001) and CTRL (P = 0.021).”
Effects of added chelated trace minerals, organic selenium, yeast culture, direct-fed microbials, and Yucca schidigera extract in horses. Part I: Blood nutrient concentration and digestibility.“Mean fecal Zn and Co concentrations excreted by horses consuming ADD were greater than CTRL (P < 0.003).”
“Using the combined extraction-liquid chromatography purification it was demonstrated that the microsomal 6 beta-hydroxylase active on 4-androstene-3,17-dione and progesterone was inhibited to 95% by carbon monoxide.”
“The K M for androstenedione calculated from simple single substrate experiments was 0.8μM. Aromatization of both androstenedione and 19-hydroxyandrostenedione, as well as 19-hydroxylation of androstenedione, was inhibited by carbon monoxide.”
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