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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Androstenedione
drug:
Atorvastatin
Research Papers that Mention the Interaction
“In females with PCOS, atorvastatin lowered the total testosterone, FAI, androstenedione , and DHEAS.”
“…,atorvastatin may reduce total testosterone by -0.27 nmol/L (95% CI -0.50 … by -2.59 nmol/L (95% CI -3.62 to -1.57), androstenedione by -1.37 nmol/L (95% CI -2.26 to -0.… -0.63 μmol/l (95% CI -1.12 to -0.15).”
Effect of atorvastatin on testosterone levels.“Although both treatments decreased plasma levels of total and LDL-cholesterol levels, only high-dose atorvastatin reduced serum levels of total testosterone, free testosterone and androstendione.”
“Conclusions Twelve weeks of atorvastatin significantly reduced both DHEAS and androstenedione contributing to the total reduction of androgen concentrations and indicating that the reduction of the hyperandrogenaemia could be partly due to the action of atorvastatin at both the ovary and the adrenal gland in PCOS.”
“There was a … reduction of androstenedione (5.7 [0.8] versus 4.7 [0.7] nmol/L; P = 0.03) and DHEAS (7.1 [1.0] versus 6.0 [0.9] μmol/L; P = 0.02) with three months of atorvastatin while there were no significant changes with placebo.”
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