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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Andrographolide
drug:
Aldesleukin
Research Papers that Mention the Interaction
“Moreover, andrographolide reduces IFN-gamma and IL-2 production induced by concanavalin A in murine T-cell.”
Andrographolide reduces IL-2 production in T-cells by interfering with NFAT and MAPK activation.“Taken together our results demonstrate that APE and ANDLE inhibit the tumor specific angiogenesis by regulating the production of various pro and antiangiogenic factors such as proinflammatory cytokine, nitric oxide, VEGF, IL-2 and TIMP-1.”
“Moreover, treatment of APE and ANDLE significantly elevated the production of interleukin-2 and interferon-γ in normal and Ehrlich ascites carcinoma-bearing animals.”
“ Andrographolide , but not 14-DAP, inhibited partially the IL-2 production induced by CON-A. Andrographolide at doses of 5 and 10 microM reduced the extracellular-signal-regulated protein kinase (ERK1/2) phosphorylation induced by CON-A, whereas 14-DAP only reduced ERK1 and partially the ERK2 phosphorylation.”
Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis.
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