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Discover Supplement-Drug Interactions

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Last Updated: 5 months ago

Possible Interaction: Amsacrine and Glutathione



Research Papers that Mention the Interaction

All thiols tested glutathione , cysteine, coenzyme A, 2-mercaptoethanol and lactate dehydrogenase) formed adducts with mAMSA as evidenced by changes in the absorption spectrum of mAMSA and induction of fluorescence.
Biochemical pharmacology  •  1986  |  View Paper
…,glutathione plays a role in the detoxification and repair of cellular injury … such diverse agents as mechlorethamine, melphalan, cyclophosphamide, nitrosoureas, 6-thiopurine, 4'-(9-acridinylamino)methanesulfon-m-anisidide , the quinone antibiotics (including Adriamycin, daunorubicin, and mitomycin C), the sesquiterpene … (such as vernolepin), and other sulfhydryl-reactive diterpenes (like jatrophone).
Cancer research  •  1984  |  View Paper
Further, the possible involvement of GSH transferase in the conjugation of amsacrine may have consequences for the hepatotoxicity of this agent.
Drug metabolism and drug interactions  •  1988  |  View Paper