Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 5 months ago

Possible Interaction: Amsacrine and Cupric Cation

supplement:

Cupric Cation

Research Papers that Mention the Interaction

A highly fluorescent product was obtained upon reacting mAMSA with Cu(II ), with an emission spectrum (excitation at 400 nm) showing a doublet at 430 and 450 nm and a shoulder around 480 nm.
Interaction of Cu(II ) with mAMSA was characterized by a decrease in the absorption at 435 and 420 nm with a simultaneous increase at 330 nm.
We have demonstrated that 4'-(9-acridinyl-amino)methanesulfon-m-anisidide mAMSA ), in the presence of Cu(II) ion , causes the breakage of plasmid pDPT275 and pBR322 superhelical form I DNA.
Biochemistry  •  1984  |  View Paper
4'-(9-Acridinylamino)methanesulfon-m-anisidide (mAMSA) interacts with Cu(II) ion , as indicated by changes in the mAMSA absorption spectrum induced by Cu(II).
Biochemistry  •  1984  |  View Paper
Maximal DNA-breaking activity was obtained upon mixing mAMSA and Cu(II ) for 2-4 hr, depending on the concentrations of mAMSA and Cu(II), and was followed by a subsequent decrease in breakage.
Biochemical pharmacology  •  1986  |  View Paper