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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Amsacrine
supplement:
Cupric Cation
Research Papers that Mention the Interaction
“Maximal DNA-breaking activity was obtained upon mixing mAMSA and Cu(II ) for 2-4 hr, depending on the concentrations of mAMSA and Cu(II), and was followed by a subsequent decrease in breakage.”
Identification of the active species in deoxyribonucleic acid breakage induced by 4'-(9-acridinylamino)methanesulfon-m-anisidide and copper.“A highly fluorescent product was obtained upon reacting mAMSA with Cu(II) , with an emission spectrum (excitation at 400 nm) showing a doublet at 430 and 450 nm and a shoulder around 480 nm.”
“Interaction of Cu(II) with mAMSA was characterized by a decrease in the absorption at 435 and 420 nm with a simultaneous increase at 330 nm.”
“We have demonstrated that 4'-(9-acridinyl-amino)methanesulfon-m-anisidide (mAMSA), in the presence of Cu(II) ion , causes the breakage of plasmid pDPT275 and pBR322 superhelical form I DNA.”
Deoxyribonucleic acid breaks produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide and copper.“4'-(9-Acridinylamino)methanesulfon-m-anisidide mAMSA ) interacts with Cu(II) ion , as indicated by changes in the mAMSA absorption spectrum induced by Cu(II).”
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