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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Amphotericin B
supplement:
Vitamin E
Research Papers that Mention the Interaction
“Furthermore, the addition of vitamin C and vitamin E protects human red blood cells against the cytotoxicity induced by amphotericin B with 17%.”
Effects of ascorbic acid and α-tocopherol on the therapeutic index of amphotericin B.“Moreover, the level of TBARS formed in the reaction medium of AmB was significantly reduced after combination with ascorbic acid and α-tocopherol.”
“Results: Based on the findings, the addition of ascorbic acid (3×102 µg/mL) and α-tocopherol (16 µg/mL) to the reaction medium of AmB increased its antifungal activity while maintaining its molecular stability.”
Influence of ascorbic acid and α-tocopherol on the autoxidation and in vitro antifungal activity of amphotericin B“Addition of three emulsifying agents poly vinyl pyrrolidone (PVP), Vitamin E (TPGS) and pluronic F-68 to AmB formulations led to a significant reduction in particle size and increase in drug entrapment efficiency (DEE) compared to addition of PVP alone.”
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