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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Amphotericin B
supplement:
Trehalose
Research Papers that Mention the Interaction
“In addition, AMB triggered a Hog1-independent synthesis of trehalose.”
The MAPK Hog1 mediates the response to amphotericin B in Candida albicans.“ AmB induced significant synthesis of endogenous trehalose in parental cells, due to the transitory accumulation of TPS1 mRNA or to the moderate activation of trehalose synthase (Tps1p) with the simultaneous deactivation of neutral trehalase (Ntc1p).”
“With exponential phase cells, in the presence of AmB , the consumption of glucose and the production of ethanol, trehalose , and glycerol continuously decreased with time, and after 25 min, the metabolism was blocked.”
“ Amphotericin B has been found to exert a marked influence on the glucose consumption and the production of all metabolites; for example, at 1 microM, the glucose consumption and the production of ethanol decrease while the production of glycerol and trehalose increases.”
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