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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Amphotericin B
supplement:
Potassium
Research Papers that Mention the Interaction
“The effects of amphotericin B on cell lipid metabolism are partially reversed by both potassium and insulin.”
The effects of amphotericin B on lipid metabolism in cultured human skin fibroblasts“The … potassium … amphotericin B increased an‘d giomeruiar filtration rate fell; (2) development of renal tubular acidosis ‘in five of six patients, the primary change being decrease … load, a rise in urine pH or fail in hydrogen ion excretion tended to precede a significant fail in giomeruiar filtration rate.”
“The … potassium … amphotericin B increased and glomerular filtration rate fell; (2) development of renal tubular acidosis in five of six patients, the primary change being decrease in … load, a rise in urine pH or fall in hydrogen ion excretion tended to precede a significant fall in glomerular filtration rate.”
“However, the D/P as well as the KBD values for potassium were significantly higher in the H-AmB and L-AmB groups as compared to the control group, resulting in significantly higher potassium clearances among the two AmB groups as compared to the control group.”
Amphotericin B does not increase peritoneal fluid removal.“At the whole-cell level, amphotericin B altered potassium conductances in two types of these cells categorized on the basis of whole-cell potassium currents.”
“It is shown that amphotericin B (5×10-5 M) increases the permeability of the frog skin to potassium , chloride and urea.”
“When the medium potassium is 5.1 mM., amphotericin B decreases slice inulin space and calculated intracellular potassium concentration as well as PAH uptake.”
“… potassium release from the cells and the incorporation rate of 14C-amino … of C. albicans, strain R3, under the action of amphotericin B are lower as compared to the susceptible culture; therefore, the resistance of C. … be due to a decrease in the degress of its disordered selective permeability.”
[Composition and certain properties of Candida albicans cells with a low level of resistance to polyene antibiotics].“Studies on the reversion of the protein synthesis blockade by amphotericin B by increasing the potassium concentration in the medium suggest that changes in the potassium concentration in cellular cytoplasm might be responsible, at least in part, for the inhibition of protein synthesis.”
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