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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Amphotericin B and Mechlorethamine

Research Papers that Mention the Interaction

Abstract In HT29 human colon carcinoma cells, amphotericin B at doses above 120μg/ml increased nitrogen mustard uptake, and this was due to an increase in the apparent V max without a change in the apparent K m .
Longer incubations (24 to 48 hr) of ascites fluid human ovarian carcinoma cells or SKMES-1 human epidermoid carcinoma cells with amphotericin B 4μg/ml enhanced the uptake of nitrogen mustard to a greater degree than that observed when cells were incubated for only 30 min.
Therefore, amphotericin B can enhance nitrogen mustard by human tumor cell lines and by fresh human tumor cells.
Biochemical and biophysical research communications  •  1980  |  View Paper