Possible Interaction: Amphotericin B and Glycerol

“For both exponential and stationary phase cells, AmB induced an increase in the membrane permeability to glycerol ; no change was observed for the other metabolites.”

“With exponential phase cells, in the presence of AmB , the consumption of glucose and the production of ethanol, trehalose, and glycerol continuously decreased with time, and after 25 min, the metabolism was blocked.”

“The lipid-soluble hydrophobic properties of amphotericin B appear to be important for this synergistic effect, in that alkyl glycerol ethers could promote synergism with amphotericin B by potentially increasing the interaction between membrane-bound ergosterol and amphotericin B.”

“In the presence of 10(-6) M AMB , the glycerol C1,3 resonance drastically decreases at 20 min and then disappears in the noise.”

“ Amphotericin B has been found to exert a marked influence on the glucose consumption and the production of all metabolites; for example, at 1 microM, the glucose consumption and the production of ethanol decrease while the production of glycerol and trehalose increases.”