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Last Updated: 2 years ago

Possible Interaction: Amphotericin B and Glucose

supplement:

Glucose

Research Papers that Mention the Interaction

The clearance (CL) of AmB in dextrose (0.039 ± 0.016 liter · h−1 · kg−1) was significantly lower (P < 0.005) than the CL of AmB in lipid emulsion (0.062 ± 0.024 liter · h−1 · kg−1).
The steady-state volume of distribution for AmB in dextrose (0.83 ± 0.33 liter · kg−1) was also significantly lower (P < 0.005) than that for AmB in lipid emulsion (1.47 ± 0.77 liter · kg−1).
Antimicrobial Agents and Chemotherapy  •  1999  |  View Paper
The effect of glucose on intracellular ionized magnesium was blocked by amphotericin B and the EC(50) of the effect of glucose on intracellular ionized magnesium was about 5 mmol/l of glucose.
Life sciences  •  2002  |  View Paper
Ultrafiltration due to the osmotic gradient induced by the dextrose content of the dialysis solution increased significantly to 0.31 mL/kg/min with amphotericin B , compared with control values of 0.18 mL/kg/min.
American journal of kidney diseases : the official journal of the National Kidney Foundation  •  1984  |  View Paper
Addition of amphotericin B after exposure to cholera toxin or to the hypertonic solutions resulted in a further significant reduction of absorption of glucose and ethylene glycols (p less than 0.05).
In the colon the administration of amphotericin B after the exposure to cholera toxin resulted in enhanced absorption of glucose (p less than 0.05) in spite of continuing fluid secretion.
The Journal of laboratory and clinical medicine  •  1983  |  View Paper
With exponential phase cells, in the presence of AmB , the consumption of glucose and the production of ethanol, trehalose, and glycerol continuously decreased with time, and after 25 min, the metabolism was blocked.
Canadian journal of microbiology  •  1996  |  View Paper
Amphotericin B was shown to have the following effects on metabolism in intact yeasts: inhibition of endogenous O 2 uptake; inhibition of oxidation of glucose and acetate; possible alteration of cell permeability; inhibition of glycolysis.
The Journal of pharmacology and experimental therapeutics  •  1960  |  View Paper