Possible Interaction: Amphotericin B and Antioxidants

“Lysis of human erythrocytes induced by amphotericin B was retarded when the oxygen tension of the incubation mixture was reduced or when the antioxidant catalase was added; lysis was accelerated when cells were preincubated with the prooxidant ascorbate.”

“Co-treatment with various antioxidants also demonstrated reciprocal effects on susceptibility towards FLC and AMB.”

“Temperature increased AmB loss in a nonlinear behavior and the presence of antioxidants reduced its degradation.”

“Although antioxidants enhanced the antifungal properties of both amphotericin B and its methyl ester derivative, the effect was significantly more pronounced with amphotericin B. This disparity is explained on the basis of differences observed in the dynamics of drug action.”

“Although synergism was not seen in tests with a strain of Torulopsis glabrata, antioxidants prolonged the inhibitory action of AB against this organism.”

“On the basis of these findings and other considerations that are discussed, it is suggested that stabilization of AB and the ability to act synergistically with AB represent two distinctly different effects of the antioxidants.”

“Results of earlier turbidimetric growth experiments showed that certain antioxidants prolonged the antifungal activity of amphotericin B (AB) against Candida albicans, presumably by retarding autoxidative destruction of the drug.”