Possible Interaction: Amphotericin B and Allicin

“45% reduction of amastigote burden with 0.05 μM AmB plus 10 μM allicin ); this represented nearly a 2-fold reduction in the 50% inhibitory concentration (IC50) of the antibiotic added alone.”

“ Allicin enhanced the activity of AmB on intracellular amastigotes of Leishmania donovani and L. infantum (ca.”

“Results obtained showed, using a fixed-ratio analysis, that the combination of diallyl thiosulfinate allicin ) and AmB ranged from moderately synergic to synergic at low concentrations (0.07 μM AmB plus 35.45 μM allicin induced 95% growth inhibition).”

“Further study first demonstrated that allicin-mediated oxidative damage, such as phospholipid peroxidation in the plasma membrane, via influencing the … damage may be the cause of the synergistic interaction between allicin and AmB. We envision that a combination of AmB … allicin may prove to be … therapy of disseminated candidiasis.”

“In addition to the interaction of AmB with ergosterol in the fungi cell … oxidative damage involved in the fungicidal activity of AmB. In this study, allicin , an allyl sulphur compound from … enhance significantly the effect of AmB against Candida albicans in vitro and … did not exert a fungicidal effect.”

“The synergistic fungicidal activities of AmB and allicin may have significant implications for the development of vacuole-targeting chemotherapy against fungal infections.”

“Cells treated with AmB + allicin had a greater adhesive force than cells treated with AmB alone because of the secretion of molecules due to collapsed membranes.”

“In particular, cells treated with allicin + AmB had significant membrane damage (burst or collapsed membranes).”

“These results suggest that allicin can reduce MIC of AmB while keeping the same efficacy.”

“ Allicin selectively enhances the fungicidal activity of amphotericin B (AmB).”

“On the other hand, in identical conditions, the combination of AmB and allicin induced both lethality and vacuole disruption.”

“Our results suggest that the fungicidal activity of AmB combined with allicin is involved in vacuole disruption but not in potassium ion efflux, and that the expression of allicin-mediated activity of AmB requires the presence of ergosterol in the plasma membrane.”

“The combined fungicidal activity of AmB and allicin was suppressed together with suppression of vacuole membrane damage in cells where ergosterol had been fully enriched in the vacuole membrane.”

“ Allicin could also enhance the antifungal activity of AmB against the pathogenic fungus Candida albicans and against Aspergillus fumigatus.”

“Amphotericin B AmB ) is a representative antibiotic for the control of serious fungal infections, and its fungicidal activity was greatly enhanced by allicin , an allyl-sulfur compound from garlic.”