Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Amphetamine and Vitamin C




Vitamin C

Research Papers that Mention the Interaction

Treatment recommendation include the use of a dopamine antagonist such as haloperidol and the use of ascorbic acid to accelerate the renal elimination of amphetamines.
American journal of hospital pharmacy  •  1977  |  View Paper
d‐Amphetamine (0.2 mM), given intranigrally, increased AA and uric acid dialysate concentrations and decreased those of glutamate, aspartate and DA; DOPAC+HVA and 5‐HIAA concentrations were unaffected.
British journal of pharmacology  •  2000  |  View Paper
Ascorbic acid (1 g/kg) accentuated anorectic and locomotor effects of amphetamine (5 mg/kg) and delayed development of tolerance to anorectic effect.
The results suggest that modulation of dopamine receptor sensitivity by ascorbic acid may be the reason for the delay in development of tolerance to amphetamine induced anorexia.
Indian journal of experimental biology  •  1994  |  View Paper
Amphetamine (which enhances dopaminergic, cholinergic, and glutamatergic activity) increases release of ascorbic acid (AA) and uric acid (UA) in the caudate nucleus.
Pharmacology Biochemistry and Behavior  •  1994  |  View Paper
Amphetamine produces dramatic changes in extracellular ascorbic acid (AA) and uric acid (UA) in rat caudate; the origin of extracellular AA and UA is being widely investigated.
Pharmacology Biochemistry and Behavior  •  1987  |  View Paper
It appears, therefore, that multiple amphetamine injections reduce the release of ascorbic acid in the neostriatum and that this effect does not depend on the integrity of dopaminergic neurons.
Brain Research  •  1986  |  View Paper
Increased extracellular ascorbic acid resulted from the amphetamine , lasting over a period of two hours.
Pharmacology Biochemistry and Behavior  •  1984  |  View Paper
Although it has been reported that ascorbic acid will decrease the urinary excretion of amphetamine by dogs, it was found that amphetamine did not reduce the blood level of ascorbic acid.
The Journal of pharmacology and experimental therapeutics  •  1947  |  View Paper