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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Amphetamine
supplement:
Vitamin C
Research Papers that Mention the Interaction
“Treatment recommendation include the use of a dopamine antagonist such as haloperidol and the use of ascorbic acid to accelerate the renal elimination of amphetamines.”
Amphetamine psychosis.“ d‐Amphetamine (0.2 mM), given intranigrally, increased AA and uric acid dialysate concentrations and decreased those of glutamate, aspartate and DA; DOPAC+HVA and 5‐HIAA concentrations were unaffected.”
On the mechanism of d‐amphetamine‐induced changes in glutamate, ascorbic acid and uric acid release in the striatum of freely moving rats“ Ascorbic acid (1 g/kg) accentuated anorectic and locomotor effects of amphetamine (5 mg/kg) and delayed development of tolerance to anorectic effect.”
“The results suggest that modulation of dopamine receptor sensitivity by ascorbic acid may be the reason for the delay in development of tolerance to amphetamine induced anorexia.”
“ Amphetamine (which enhances dopaminergic, cholinergic, and glutamatergic activity) increases release of ascorbic acid (AA) and uric acid (UA) in the caudate nucleus.”
“ Amphetamine produces dramatic changes in extracellular ascorbic acid (AA) and uric acid (UA) in rat caudate; the origin of extracellular AA and UA is being widely investigated.”
“It appears, therefore, that multiple amphetamine injections reduce the release of ascorbic acid in the neostriatum and that this effect does not depend on the integrity of dopaminergic neurons.”
“Increased extracellular ascorbic acid resulted from the amphetamine , lasting over a period of two hours.”
“Although it has been reported that ascorbic acid will decrease the urinary excretion of amphetamine by dogs, it was found that amphetamine did not reduce the blood level of ascorbic acid.”
The excretion of amphetamine.
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