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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Amphetamine
drug:
Valproic Acid
Research Papers that Mention the Interaction
“Furthermore, co-administration of BA or VPA with amphetamine produced additive effects on histone H4 acetylation as well as CREB phosphorylation in the striatum.”
Additive effects of histone deacetylase inhibitors and amphetamine on histone H4 acetylation, cAMP responsive element binding protein phosphorylation and ΔFosB expression in the striatum and locomotor sensitization in mice“Li reversed AMPH changes in NT-3 in the reversal model, and VPT prevented AMPH changes in NT-3 in the prevention model.”
“In amphetamine-pretreated animals, valproate administration reversed citrate synthase activity inhibition induced by amphetamine.”
“We found that repeated administration of VPA or BA for 6 days inhibited the expression of sensitized response following amphetamine challenge.”
“However, the co-administration of lithium or valproate with amphetamine increased lipid peroxidation, depending on the brain region and treatment regimen.”
“In this study, we tested the hypotheses that lithium and valproate would reverse and prevent the behavioral and biochemical effects of amphetamine , using a rat model of mania.”
“Although the association of VPA plus amphetamine alters some proteins involved in the JNK pathway in the hippocampus, these alterations were very random and seemed that were not related to the d-AMPH-induced manic-like behavior.”
Effects of lithium and valproate on ERK/JNK signaling pathway in an animal model of mania induced by amphetamine
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