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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Amphetamine
supplement:
Tyrosine
Research Papers that Mention the Interaction
“These findings are consistent with animal experimental studies indicating that tyrosine depletion attenuates the release of dopamine produced by amphetamine but not the release of noradrenaline.”
Attenuation of some subjective effects of amphetamine following tyrosine depletion“A high correlation was observed between nSPEED and STD studies for measurement of EDV ( Y = 0.957X, R2 = 0.99), ESV (Y = 0.962X, R2 = 0.99), and LVEF (Y = 1.005X, R2 = 0.96).”
“These findings indicate that changes in striatal tyrosine kinase-B signaling could play a role in neuroadaptations and behavioral changes induced by amphetamine treatment.”
Amphetamine increases tyrosine kinase-B receptor expression in the dorsal striatum“It is probably not due to a tryptophan-specific mechanism, because amphetamine increases the ratio of brain/plasma concentrations not only of tryptophan but also of tyrosine and phenylalanine.”
“The amino acid was most effective when given 30 minutes before amphetamine administration, at which time it also significantly lowered brain tyrosine concentration (and, presumably, suppressed catecholamine synthesis).”
“This kinetic analysis revealed that amphetamine inhibited DA synthesis by noncompetitive inhibition for tyrosine.”
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