Possible Interaction: Amphetamine and Tyramine

“Acute intravenous administration of amphetamine increased the sensitivity to both tyramine and norepinephrine to 200 to 300 per cent of control.”

“Following tachyphylaxis to tyramine , the response to phenylethylamine and amphetamine was markedly depressed, and multiple exposures to phenylethylamine diminished the initial response to amphetamine and acetylcholine.5.”

“5 The excretion of p‐tyramine but not its metabolite, p‐hydroxyphenylacetic acid, was decreased by amphetamine during treatment and returned to normal levels six days later.”

“ meta Tyramine was significantly reduced by a low dose of amphetamine and a high dose of methylphenidate but significantly increased by a high dose of amphetamine.”

“Abstract The α-methyl-substituted amines dl-α-methylbenzylamine, dl-α-methyltryptamine and the two stereoisomers of amphetamine were shown to be competitive inhibitors of the oxidation of benzylamine, tyramine and serotonin by rat liver monoamine oxidase.”

“After inhibition of MAO, amphetamine still enhanced the response to tyramine and nerve stimulation.”

“ Amphetamine similarly administered to control animals potentiated the response of the eyelid to nerve stimulation and tyramine.”

“In the anesthetized dog, the acute administration of either reserpine or amphetamine increases the pressor response to tyramine.”

“When amphetamine and reserpine were both given, in either order, the pressor responses to tyramine were diminished.”

“ Amphetamine hastened the development of tachyphylaxis to tyramine.”

“ Amphetamine prevented the "escape" from tachyphylaxis to tyramine without influencing the tyramine-induced release of catecholamine from the heart.”

“It has been shown that amphetamine enhanced the acute pressor responses to tyramine.”

“Promethazine, tyramine , guanethidine, as well as a few anticholinergics, and MAO inhibitors potentiated amphetamine and cocaine, but did not stimulate with tetrabenazine.”