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Last Updated: 2 years ago

Possible Interaction: Amphetamine and Tryptophan

supplement:

Amphetamine

supplement:

Tryptophan

Research Papers that Mention the Interaction

It was observed that: 1) parachlorophenylalanine prolonged the anticataleptic action of ephedrine and, in part also, that … an anticataleptic effect and enhanced somewhat the same effect of both psychostimulating drugs used, 3) d, 1-tryptophan increased the intensity of catalepsy and reduced … the anticataleptic action of ephedrine and amphetamine.
Acta physiologica Polonica  •  1979  |  View Paper
L-Dopa, dl-amphetamine , alpha-methyl-Dopa, parachlorophenylalanine and serotonino-blockators--deseryl and lysergide--eliminate the tranquilizing action of tryptophane on emotional reactivity, decreasing serotonin accumulation and intensifying the formation of 5-oxyindolacetic acid.
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova  •  1975  |  View Paper
Tryptophan was previously shown to increase backward walking, circling and forward walking provoked by amphetamine , but not the other three behaviours tested (Lees, Fernando and Curzon, 1979).
Neuropharmacology  •  1981  |  View Paper
The acute administration of amphetamine also caused an increase in the concentration of tryptophan and 5-HT in the brain stem, striatum and some regions of the limbic system.
Irish journal of medical science  •  1978  |  View Paper
It is probably not due to a tryptophan-specific mechanism, because amphetamine increases the ratio of brain/plasma concentrations not only of tryptophan but also of tyrosine and phenylalanine.
European journal of pharmacology  •  1978  |  View Paper