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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Amphetamine
Research Papers that Mention the Interaction
“Finally, THC exposed animals, both male and female, showed a dampened locomotor response to amphetamine , but females were more active than males overall.”
Prenatal tetrahydrocannabinol (THC) alters cognitive function and amphetamine response from weaning to adulthood in the rat.“Exposure to all but the lowest and highest doses of Δ9-THC enhanced the locomotor response to amphetamine (0.75 mg/kg i.p.),”
Previous Exposure to Δ9-Tetrahydrocannibinol Enhances Locomotor Responding to but Not Self-Administration of Amphetamine“However, both cocaine and amphetamine and D2-, but not the D1-, receptor agonists, augmented THC discrimination.”
“However, the D2-, but not the D1-, antagonist counteracted the augmentation of THC ’s discriminative effects produced by cocaine and amphetamine.”
“These findings link the sites of rewarding action of Δ9THC to brain regions where such drugs as amphetamines , cocaine, heroin, and nicotine are also thought to have their sites of rewarding action.”
“Pre-treatment with Delta(9)-THC increased the locomotor responses to amphetamine and heroin.”
“The most interesting observation was that adult females, when exposed perinatally to THC , exhibited a trend to lesser response to AMPH , in terms of decreasing DA metabolism, than oil-exposed females.”
“The dose-dependent amphetamine antagonism to the behavioural effects of THC was paralleled by a dose-related increase in brain dopamine concentration.”
“The THC effects, which included a reduction in spontaneous locomotor activity, the development of prostration, and circling behaviour, were antagonized in a dose-dependent manner by pretreatment with amphetamine.”
“This elevation in dopamine levels may be instrumental in triggering the neuronal events responsible for the amphetamine antagonism of the actions of THC.”
“However, when the interval between drug treatments was increased to two hours, THC , 10 mg/kg, minimally reduced the rate of disappearance of 14 C-amphetamine from the blood of fasted rats.”
“It is concluded that THC can inhibit amphetamine metabolism in rats depending upon the time interval between the administration of the two drugs and the dietary state of the animals.”
“Previously reported synergistic interaction between amphetamine and THC is related to aggregation of the animals rather than drug treatment.”
“Since THC at low doses can stimulate motor activity in saline-treated animals, amphetamine may act only to amplify the behavioral activity produced by low doses of THC.”
“SKF 525-A, pentobarbital, phenobarbital and amphetamine all produced an apparently non-competitive inhibition of THC metabolism.”
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