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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Amphetamine
supplement:
Taurine
Research Papers that Mention the Interaction
“At the highest dose, amphetamine increased extracellular glutamate by 445% of baseline as well as extracellular concentrations of taurine , and reduced extracellular concentrations of glutamine.”
Amphetamine Increases Extracellular Concentrations of Glutamate in the Prefrontal Cortex of the Awake Rat: A Microdialysis Study“The administration of d‐amphetamine (5.0 mg/kg × 4 ip) caused gradual fivefold increases in the extracellular glutamate and taurine levels and moderate increases in the extracellular aspartate level.”
“We conclude that a massive increase in extracellular taurine reflects hyperactivation of glutamatergic neurotransmission elicited by acute toxic dose of d‐amphetamine.”
“ Amphetamine also produced an enhancement on GABA and taurine levels, although these increases did not follow a dose-related curve.”
“Increased locomotor and behavioral activities following a high dose of amphetamine elevated taurine concentrations significantly in the substantia nigra and locus ceruleus.”
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