Possible Interaction: Amphetamine and Sulpiride

“ Sulpiride reduced the response induced by nicotine or amphetamine plus nicotine, while SCH23390 reduced normal sniffing behaviour of the animals and sniffing induced by either amphetamine or amphetamine plus nicotine.”

“The dopamine D2 receptor antagonist (-)sulpiride (0.05 and 1 microM) reversed the amphetamine (10 microM)-induced inhibition of firing activity in A9 and A10 neurons.”

“ Sulpiride also potentiated the amount of dopamine increased by 8 mg/kg amphetamine , but did so by affecting the maximum concentration achieved (P<0.05), not the onset or offset rates.”

“Both SCH-23390 and sulpiride prevented the reduction in extracellular glutamate by amphetamine.”

“After withdrawal of systemic administration of sulpiride (200 mg/kg), an enhancement of anorexia induced by systemic amphetamine was observed.”

“ Sulpiride attenuated by 36% the anorexia produced by intrahypothalamic injections of amphetamine.”

“Similar treatments with sulpiride and fluphenazine also inhibited the amphetamine‐induced hyperactivity.”

“… (–)‐sulpiride also increased the enzyme activity in striatal slices … inducing release of DA, such as veratridine and d‐amphetamine , it is concluded that the stimulating effect of the DA antagonist resulted in fact from … of the negative control of TH normally triggered by endogenous DA acting on presynaptic autoreceptors.”

“ Sulpiride blocked this action of amphetamine whereas SCH 23390 was ineffective.”

“These inhibitory effects of beta-PEA and AMPH on [3H] ACh release were antagonized by S-sulpiride (0.1 microM).”