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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Amphetamine
drug:
Substance P
Research Papers that Mention the Interaction
“The rotational responses to both dynorphin A and substance P were potentiated by injection of amphetamine 1 h later, suggesting that both peptides act via nigro-striatal dopamine neurons.”
Striato-nigral dynorphin and substance P pathways in the rat“significantly attenuated amphetamine (1.25 and 2.5 mg/kg, i.p.)-stimulated striatal preprodynorphin and, to a lesser degree, substance P messenger RNA expression.”
“As measured by quantitative in situ hybridization, acute amphetamine induced an increase in substance P , preproenkephalin A and dynorphin messenger RNA levels (+23 +/- 0.05%, +45 +/- 0.07% and +24 +/- 0.05%, respectively).”
“ Chronic amphetamine treatment enhanced only substance P and dynorphin messenger RNA levels (+23 +/- 0.04% and +42 +/- 0.04%, respectively).”
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