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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Amphetamine and Spiperone



Research Papers that Mention the Interaction

Low doses of butyrophenones (haloperidol and spiroperidol ) inhibited the rise in cyclic GMP levels and the stereotyped behaviour induced by amphetamine , but were without effect on the same biochemical and behavioural changes elicited by apomorphine.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
The dopamine antagonists sulpiride and spiperone were both ineffective against the acute response to amphetamine ; nevertheless, both blocked the induction of sensitization, suggesting that the mesocortical dopamine pathway is not involved in the acute response but is necessary for the induction of sensitization.
Brain Research  •  1997  |  View Paper
The DA antagonist, spiroperidol (50-200 micrograms/kg) failed to attenuate the hyperactivity-reducing effect of amphetamine in 6-OHDA-treated rats at doses which abolished the stimulant effect of amphetamine in control rats.
Brain Research  •  1982  |  View Paper
Amphetamine doses from 8.0 to 64.0 mg/kg failed to stimulate behavior significantly and consistently after spiperone treatment.
European journal of pharmacology  •  1977  |  View Paper