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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Amphetamine
drug:
Spiperone
Research Papers that Mention the Interaction
“Low doses of butyrophenones (haloperidol and spiroperidol ) inhibited the rise in cyclic GMP levels and the stereotyped behaviour induced by amphetamine , but were without effect on the same biochemical and behavioural changes elicited by apomorphine.”
Dopaminergic stimulants and cyclic nucleotides in mouse brain“The dopamine antagonists sulpiride and spiperone were both ineffective against the acute response to amphetamine ; nevertheless, both blocked the induction of sensitization, suggesting that the mesocortical dopamine pathway is not involved in the acute response but is necessary for the induction of sensitization.”
The role of the frontal cortex in the mouse in behavioral sensitization to amphetamine“The DA antagonist, spiroperidol (50-200 micrograms/kg) failed to attenuate the hyperactivity-reducing effect of amphetamine in 6-OHDA-treated rats at doses which abolished the stimulant effect of amphetamine in control rats.”
“ Amphetamine doses from 8.0 to 64.0 mg/kg failed to stimulate behavior significantly and consistently after spiperone treatment.”
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