Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Amphetamine and Spiperone

supplement:

Amphetamine

Research Papers that Mention the Interaction

Low doses of butyrophenones (haloperidol and spiroperidol ) inhibited the rise in cyclic GMP levels and the stereotyped behaviour induced by amphetamine , but were without effect on the same biochemical and behavioural changes elicited by apomorphine.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
The dopamine antagonists sulpiride and spiperone were both ineffective against the acute response to amphetamine ; nevertheless, both blocked the induction of sensitization, suggesting that the mesocortical dopamine pathway is not involved in the acute response but is necessary for the induction of sensitization.
Brain Research  •  1997  |  View Paper
The DA antagonist, spiroperidol (50-200 micrograms/kg) failed to attenuate the hyperactivity-reducing effect of amphetamine in 6-OHDA-treated rats at doses which abolished the stimulant effect of amphetamine in control rats.
Brain Research  •  1982  |  View Paper
Amphetamine doses from 8.0 to 64.0 mg/kg failed to stimulate behavior significantly and consistently after spiperone treatment.
European journal of pharmacology  •  1977  |  View Paper