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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Amphetamine
drug:
Sertraline
Research Papers that Mention the Interaction
“ Abstract Sertraline dose-dependently increased the locomotor stimulating effect of amphetamine.”
“Further, there was an increase in the concentration of amphetamine in the brain in rats pretreated with 5 mg/kg sertraline.”
“It is probable that sertraline and fluoxetine augment the locomotor stimulatory effect of amphetamine by decreasing the metabolism of amphetamine, perhaps via actions on cytochrome P450 isozymes.”
The potentiating effect of sertraline and fluoxetine on amphetamine-induced locomotor activity is not mediated by serotonin
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