Possible Interaction: Amphetamine and Serotonin

“Addiction to psychostimulants, including cocaine and amphetamine , is associated with dysregulation of dopamine and serotonin (5-HT) neurotransmitter systems.”

“ Substituted amphetamines selectively tax energy metabolism in 5-HT presynapses through their ability to exchange with 5-HT and to dissipate transmembrane ion gradients.”

“Pronounced behavioural depression was observed 12 h after the withdrawal of amphetamine; 24 h after withdrawal, behaviour was … recurred at 36 h. Recovery appeared to be complete after 48 h. Fluorimetric determinations showed that noradrenaline and 5-hydroxytryptamine concentrations were … administration of amphetamine in the cortex, … and mid-brain.”

“In addition, it has been shown that morphine, amphetamine , cocaine, and nicotine self-administration, as well as intracranial self-stimulation, are all decreased following 5-HT uptake inhibition.”

“It is suggested that the release of serotonin in the ventral region of the caudate nucleus intensified by phenamine may be responsible for the limitation of the amplitude and regulating the nature of the stereotype movements evoked by it.”

“The ability of phenamine to upset the behavioral and electrographic characteristics of the caudate nucleus activity was somewhat attenuated by 5-HT and potentiated by PCPA.”

“ Amphetamine salts are an often-overlooked agent that potentiates serotonin through monoamine oxidase inhibitor (MAO) inhibition and neurotransmitter release.”

“Some transporters reverse to release transmitters, like dopamine or serotonin , when activated by 'indirectly acting' substrates, like the amphetamines.”

“In human, there are some evidence of persistant deteriorations of the serotoninergic and dopaminergic systems in the caudate nucleus, the putamen and the nucleus accumbens following amphetamine consumption.”

“Abstract Phencylidine, ketamine and fluoxetine inhibited serotonin (5-HT) uptake in a non-competitive manner in human blood platelets whereas d- and 1-amphetamine produced a competitive inhibition of 5-HT uptake.”

“ AMPH exposure was able to increase 5-HT uptake as well as oxidative damage in the PFC, whereas (m-CF3-PhSe)2 treatment exerted a preventative effect against these alterations.”