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“Previous risperidone administration enhanced amphetamine CPP regardless of sex, and this effect appeared more prominent in the developmentally treated group.”
“Using rats as a model, research has demonstrated that administration of the antipsychotic drug, risperidone , during early postnatal development elevates locomotor activity and sensitivity to the locomotor effects of amphetamine during adulthood.”
“Increased brain MDA and TNF-α levels due to amphetamine were significantly reduced in groups treated with celecoxib+risperidone or omega-3+ risperidone.”
“Lesioned animals treated with a moderate dose of risperidone (1.4 mg/kg) also exhibited significantly more locomotor activity after amphetamine treatment in comparison to control animals.”
“The D2/5-HT2A antagonists MDL 28,133A and risperidone attenuated the effects of cocaine and amphetamine , but only at antagonist doses that elevated baseline self-stimulation thresholds.”