Possible Interaction: Amphetamine and Reserpine

“ Amphetamine lowered DOPAC in reserpinized rats, and this effect was not prevented by methylphenidate.”

“The behavioral effects of amphetamine, in contrast to those induced by norepinephrine, appear to be dependent upon the functional levels of brain catecholamines as indicated by the suppression of amphetamine effects following pretreatment with alpha-methyl-p-tyrosine or reserpine.”

“Excitation and stereotypies were induced in the combined presence of reserpine and α-MpT by apomorphine, and by higher doses of some amphetamine analogues.”

“Furthermore, it was shown that reserpine treatment precluded the effects of single AMPH treatment on cellular migration to the lung of OVA-sensitized and challenged rats.”

“ Amphetamine caused a release of dopamine, instead of noradrenaline, from the noradrenaline nerves after pretreatment with reserpine , and this replacement accounted for about two thirds of the missing noradrenaline.”

“In contrast, amphetamine stimulated DA release was significantly reduced in male rats treated with reserpine.”

“Low doses of the drugs and combinations of low doses of metamphetamine , propylhexedrine and biperiden did not influence electroseizure threshold, but inhibited the action of reserpine.”

“Pretreatment with cocaine (10 mg/kg) or reserpine (2.5 mg/kg) potentiated the effects of 1 mg/kg AMPH on PEA and 3MT levels in the frontal cortex and of 3MT in the striatum.”

“In both structures, it was observed that reserpine treatment significantly attenuated the release of dopamine evoked by a high dose of amphetamine (10 mg/kg, i.p.)”

“Combined pretreatment with reserpine (3 h) and alpha-methyl-p-tyrosine (1 h) drastically reduced the increase in extracellular dopamine by both doses of amphetamine (0.5 and 2 mg/kg s.c.).”