Possible Interaction: Amphetamine and Raclopride

“ Amphetamine (1 mg/kg) increased and raclopride (0.3 mg/kg) decreased performance by 63 and 28 %, respectively, with a 20-min injection-test interval.”

“ResultsSCH 23390, SCH 39166, haloperidol, and raclopride dose-dependently inhibited vocalizations under AMPH and suppressed the proportion of trill calls.”

“In the first set of experiments, all types of AIMs (axial, limb, orolingual and locomotor) were markedly reduced when amphetamine was co-administered with either the D(2) dopamine receptor antagonist raclopride or the D(1) receptor antagonist SCH23390.”

“Even though the group given SCH23390 or raclopride alone showed profound disruption on DRL behavior by flattening the IRT curve, the co-administration of amphetamine with SCH23390 or raclopride reversed the aforementioned amphetamine-induced behavioral deficiency on DRL task.”

“The administration of amphetamine (1 mg/kg) induced a clear CPP that was completely blocked by the DA antagonists flupentixol (0.25 mg/kg) or raclopride (0.125 mg/kg).”

“A reduction of 20–30% in raclopride binding was observed 30 min after amphetamine injection (4 mg/kg IP).”

“ResultsAdministration of raclopride or clozapine reversed either an amphetamine or a ketamine-induced PPI deficit, as had the novel mood stabilizer lamotrigine in previous studies.”

“However, pretreatment with either SCH 23390 or raclopride abolished the stimulatory effect of d‐amphetamine on NT‐LI and NPY‐LI.”

“Pretreatment with either SCH 23390 or raclopride abolished the stimulatory effect of d‐amphetamine on CGRP‐LI levels.”

“In contrast, the D2 receptor‐selective antagonist raclopride induced RGS2 mRNA when administered alone and greatly enhanced stimulation by amphetamine.”