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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Amphetamine
supplement:
Quinidine
Research Papers that Mention the Interaction
“ AP deamination with purified rabbit CYP2C3, which was previously identified as the major isozyme responsible for this metabolism, was extensively inhibited with quinidine , previously thought to be a specific inhibitor of CYP2D.”
“Deamination of AP in rabbit was extensively inhibited only with quinidine.”
Major role of the CYP2C isozymes in deamination of amphetamine and benzphetamine: evidence for the quinidine-specific inhibition of the reactions catalysed by rabbit enzyme.“Prior administration of quinidine is known to reduce aromatic oxidation of amphetamine and its analog methoxyphenamine by inhibiting the cytochrome P450IID6 results in isozyme.”
“These data show that quinidine inhibits in vivo metabolism of amphetamine in rats and suggest that amphetamine metabolism may, in part, be mediated by an isozyme of P450 which displays genetic polymorphism.”
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