Possible Interaction: Amphetamine and Promethazine

“In mice, chlorcyclizine, mepyramine and promethazine inhibited amphetamine hypermotility, while others antihistaminics were without effect.”

“Other drugs found to inhibit p-hydroxylation of amphetamine were: imipramine, nortriptyline, protriptyline, Lu 3-010 (ftalan-derivative), chlorpromazine, promethazine , chlorprothixene, prochlorperazine, chlordiazepoxide, diazepam, nialamide and cocaine.”

“ Promethazine , tyramine, guanethidine, as well as a few anticholinergics, and MAO inhibitors potentiated amphetamine and cocaine, but did not stimulate with tetrabenazine.”