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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Amphetamine
drug:
Phentolamine
Research Papers that Mention the Interaction
“alpha-Adrenoceptor blocking agents: phenoxybenzamine, phentolamine and aceperone, potentiated and prolonged amphetamine and apomorphine stereotypy in the rat, but inhibited the amphetamine hypermotility.”
The effect of alpha-adrenolytics on central action of agonists and antagonists of dopaminergic system.“ Phentolamine and prazosin inhibited the direct response to adrenaline, dopamine and amphetamine , and the amphetamine-facilitated response to adrenaline and dopamine; they were inactive against serotonin alone and combined with a facilitating dose of amphetamine or dopamine.”
Facilitating effect of amphetamine on the response of rabbit aortic strips to adrenaline, dopamine and serotonin“Combined alpha- and beta-adrenergic blockade phentolamine , 1.0 mg/kg+propranolol, 2.5 mg/kg) prevented this effect of amphetamine on proliferation.”
“ Phentolamine , a direct acting alpha-adrenergic receptor antagonist was also found to block or reverse the effect of amphetamine.”
“The effects of tyramine, ephedrine and amphetamine are inhibited by phentolamine in an remarkably low dose range (pA2 = 13.51 +/- 0.09; 14.54 +/- 0.31; 14.35 +/- 0.12).”
“Thus, after treatment of rats with phentolamine, amphetamine decreased the plasma concentrations of the three aromatic amino acids; however, as the brain concentrations were little altered, the brain/plasma concentration ratios rose.”
“ Phentolamine , an alpha-adrenergic antagonist, potentiated the anorectic effect of amphetamine and l-dopa.”
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