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Last Updated: 3 years ago

Possible Interaction: Amphetamine and Phentolamine



Research Papers that Mention the Interaction

alpha-Adrenoceptor blocking agents: phenoxybenzamine, phentolamine and aceperone, potentiated and prolonged amphetamine and apomorphine stereotypy in the rat, but inhibited the amphetamine hypermotility.
Polish journal of pharmacology and pharmacy  •  1977  |  View Paper
Phentolamine and prazosin inhibited the direct response to adrenaline, dopamine and amphetamine , and the amphetamine-facilitated response to adrenaline and dopamine; they were inactive against serotonin alone and combined with a facilitating dose of amphetamine or dopamine.
Journal of Neural Transmission / General Section JNT  •  2005  |  View Paper
Combined alpha- and beta-adrenergic blockade phentolamine , 1.0 mg/kg+propranolol, 2.5 mg/kg) prevented this effect of amphetamine on proliferation.
Brain, Behavior, and Immunity  •  1993  |  View Paper
Phentolamine , a direct acting alpha-adrenergic receptor antagonist was also found to block or reverse the effect of amphetamine.
Neuroscience  •  1982  |  View Paper
The effects of tyramine, ephedrine and amphetamine are inhibited by phentolamine in an remarkably low dose range (pA2 = 13.51 +/- 0.09; 14.54 +/- 0.31; 14.35 +/- 0.12).
Acta physiologica Academiae Scientiarum Hungaricae  •  1981  |  View Paper
Thus, after treatment of rats with phentolamine, amphetamine decreased the plasma concentrations of the three aromatic amino acids; however, as the brain concentrations were little altered, the brain/plasma concentration ratios rose.
European journal of pharmacology  •  1978  |  View Paper
Phentolamine , an alpha-adrenergic antagonist, potentiated the anorectic effect of amphetamine and l-dopa.
Pharmacology Biochemistry and Behavior  •  1975  |  View Paper