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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Amphetamine
drug:
Phenoxybenzamine
Research Papers that Mention the Interaction
“alpha-Adrenoceptor blocking agents: phenoxybenzamine , phentolamine and aceperone, potentiated and prolonged amphetamine and apomorphine stereotypy in the rat, but inhibited the amphetamine hypermotility.”
The effect of alpha-adrenolytics on central action of agonists and antagonists of dopaminergic system.“ Phenoxybenzamine (4 mg/kg) constricted primarily the pupil of the innervated iris and completely antagonized the effects of the catecholamines on the irides and amphetamine on the nictitating membranes, but only partially antagonized amphetamine-induced mydriasis.”
Actions of amphetamine and antagonists on pupil diameter in the chronic sympathectomized dog“ Phenoxybenzamine (5 mg/kg) reduces the inhibitory action of amphetamine on the bradykinin-induced activity in the ventrolateral columns.”
“Haloperidol (2.0 mg/kg), propranolol (10 mg/kg) and phenoxybenzamine (30 mg/kg) were tested for ability to antagonize the lethal effects of amphetamine and its derivatives.”
“5 d‐Propranolol, chlorpromazine and phenoxybenzamine antagonized the glycogenolytic effect of amphetamine only when administered in sedative doses.”
“Chlorpromazine and phenoxybenzamine partially antagonized the sharp rise in temperature following the administration of amphetamine , and also significantly reduced mortality.”
“The analeptic effect of amphetamine was significantly inhibited by phenoxybenzamine (1.0 to 2.0 mg/kg), chlorpromazine (1.0 to 2.0 mg/kg), and Dibenamine (10 to 20 mg/kg).”
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