Possible Interaction: Amphetamine and Phenethylamines

“ PEA potentiated the amphetamine and apomorphine stereotypy but inhibited amphetamine hypermotility: in the latter experiment slight periodical stereotyped head movements were observed.”

“In general, the phenethylamine analogs were approximately 10-fold less potent than amphetamine.”

“Following tachyphylaxis to tyramine, the response to phenylethylamine and amphetamine was markedly depressed, and multiple exposures to phenylethylamine diminished the initial response to amphetamine and acetylcholine.5.”

“The mice receiving PEA were also more sensitive to the stimulatory effect of amphetamine and PCP.”

“3 Amphetamine increased the excretion of PEA and decreased that of its major metabolite, phenylacetic acid (PAA).”

“7 Since PEA elicits many behavioural changes similar to those seen with amphetamine, and since amphetamine increases PEA excretion, we suggest that amphetamine may exert some of its behavioural responses through the release of PEA.”

“Previous administration of imipramine or amphetamine decreased the recoveries of PEA and PAAc.”

“Methyldopa (α-methyl-3,4-dihydroxyphenyl-alanine), α-methyl- meta -tyrosine and their respective α-methyl-dihydroxyphenethylamines were demonstrated to be capable of antagonizing the cardiovascular actions of phenethylamine and amphetamine, but not norepinephrine, after appropriate pretreatment in dogs.”