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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Amphetamine
drug:
Pentobarbital
Research Papers that Mention the Interaction
“With Pentobarbital this increase significantly exceeded the placebo group, the d‐Amphetamine group , and those previously obtained in a variety of stress situations.”
Effects of Amphetamine and Barbiturate on Body Experience“Similarly, the administration of a combination of amphetamine and pentobarbital to seven subjects before they went to bed resulted in a significant decrease in percentage REM period time as compared with nights on which pentobarbital alone was administered.”
“The administration of amphetamine and pentobarbital to three subjects for three or four consecutive nights produced percentage REM period times below their normal values.”
“The response-rate decreasing effects of pentobarbital and amphetamine were mutually antagonized when the drugs were combined, but the rate-decreasing effects of morphine and methamphetamine were not.”
Effects of amphetamine-CNS depressant combinations and of other CNS stimulants in four-choice drug discriminations.“All three doses of amphetamine (0.5, 1.0, and 2.0 mg/kg) and pentobarbital (2.5, 5.0, and 10.0 mg/kg) significantly lowered rate-frequency M(50) values.”
“It prolonged the duration of sleep induced by pentobarbital and antagonized the effect of D‐amphetamine.”
“ Pentobarbitone induced sleep was potentiated and amphetamine induced stereotypy was inhibited.”
“In 'dual substitution' tests, mixtures of amphetamine plus pentobarbitone produced full generalization under AND-discrimination conditions, and partial generalization in the AND-OR procedure.”
“The similarity with findings reported previously for training with mixtures of amphetamine plus pentobarbitone suggests that this may reflect a general principle rather than a phenomenon restricted to particular training drugs.”
“Haloperidol (HAL), chlorpromazine (CPZ), morphine (MOR), pentobarbital (PENT), chlordiazepoxide (CDP), meprobamate (MPB), and amphetamine (AMPH) dose dependently inhibited both behaviors.”
“Thus, amphetamine produced a rewarding effect while pentobarbital was aversive.”
“Preconditioning pentobarbital with a high dose of amphetamine allows it to attenuate saccharin aversions produced by lithium and by gamma radiation (as well as by amphetamine itself).”
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