Possible Interaction: Amphetamine and Pargyline

“When combining amphetamine and pargyline treatment, H2O2 production was accelerated in the initial phase but dropped to control levels at 30 min.”

“The reuptake inhibitors, nomifensine, dichlofensine and amphetamine , in the presence of pargyline , a monoamine oxidase inhibitor, stimulated both basal and K(+)-evoked release of DA from the SME and PP under static incubation conditions.”

“Bound spin labeled amphetamine was also displaceable by pargyline.”

“ Pargyline was found to inhibit binding of spin labeled amphetamine by cytosolic monoamine oxidase.”

“The acetylenic monoamine oxidase inhibitors, pargyline and clorgyline, have been used to modulate the binding of spin labeled amphetamine.”

“4 The administration of amphetamine 4 h after pargyline resulted in a decrease in brain glycogen similar to that seen after amphetamine alone.”

“ Pargyline was less effective in potentiating the stimulant actions of amphetamine , and had no significant effect on the disappearance of amphetamine from the brain.”

“Nialamide, pargyline and tranylcypromine, three monoamine oxidase inhibiting drugs, and the microsomal enzyme inhibitor SKF 525‐A significantly decreased the amount of amphetamine removed from the portal circulation of the isolated perfused liver of the cat.”

“The degree of potentiation of amphetamine toxicity by monoamine oxidase inhibitors varied from one to another, the range being from pargyline , which increased the toxicity of amphetamine about 3-fold, to mebanazine which increased it about 100-fold.”

“Injection of amphetamine (2 mg), but not Cholecystokinin octapeptide, in rats pretreated with pargyline increased the concentration of 3‐methoxytyramine in the dorsal striatum and this effect was blocked by pretreatment with α‐methyl‐ρ‐tyrosine.”