Possible Interaction: Amphetamine and Oxytocin

“Results indicate that OT modulates parental proximity to the infant, as well as the father's head speed and head acceleration but not the father's vocalization during dyadic interaction.”

“That study, conducted in rats, revealed that systemically administered oxytocin , similar to most atypical antipsychotics, reversed prepulse inhibition deficits induced by amphetamine and the phencyclidine analog, MK801 [1].”

“ AMPH exposure also altered OT and DA neurotransmission in regions that mediate partner preference formation: it decreased OT and DA D2 receptor immunoreactivity in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAcc), respectively, and increased NAcc DA levels.”

“Together, these data suggest that repeated AMPH exposure impairs pair bonding through an OT-mediated mechanism, and that OT and DA systems within brain reward circuitry may interact to mediate the complex relationship between drug abuse and social bonding.”