Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Amphetamine and Oxytocin





Research Papers that Mention the Interaction

Results indicate that OT modulates parental proximity to the infant, as well as the father's head speed and head acceleration but not the father's vocalization during dyadic interaction.
Biology Letters  •  2013  |  View Paper
That study, conducted in rats, revealed that systemically administered oxytocin , similar to most atypical antipsychotics, reversed prepulse inhibition deficits induced by amphetamine and the phencyclidine analog, MK801 [1].
Expert review of neurotherapeutics  •  2011  |  View Paper
AMPH exposure also altered OT and DA neurotransmission in regions that mediate partner preference formation: it decreased OT and DA D2 receptor immunoreactivity in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAcc), respectively, and increased NAcc DA levels.
Together, these data suggest that repeated AMPH exposure impairs pair bonding through an OT-mediated mechanism, and that OT and DA systems within brain reward circuitry may interact to mediate the complex relationship between drug abuse and social bonding.
The Journal of Neuroscience  •  2014  |  View Paper