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Last Updated: 3 years ago

Possible Interaction: Amphetamine and Nomifensine

supplement:

Amphetamine

Research Papers that Mention the Interaction

Both early (30 min) and late (24 h) analgesic effects of cathinone were prevented by reserpine or p-chlorophenylalanine, which deplete catecholamines or serotonin, respectively, and by nomifensine , which prevents neuronal uptake of biogenic amines and amphetamines.
Pharmacology  •  1984  |  View Paper
Conversely, DAT inhibitors, such as cocaine, mazindol, and nomifensine , when administered with AMPH , blocked the reduction in [(3)H]DA uptake and the redistribution of DAT immunofluorescence to the cytosol.
Proceedings of the National Academy of Sciences of the United States of America  •  2000  |  View Paper
Combination treatment with amphetamine and nomifensine produced waking activity greater than the sum of their individual activities alone while ameliorating the amphetamine-like RHS.
In rat synaptosomes, nomifensine reduced the potency of amphetamine to induce DA release approximately 270-fold, potentially explaining its action in ameliorating amphetamine-induced RHS.
Sleep  •  2009  |  View Paper
The effect of amphetamine on synapsin I phosphorylation was blocked by nomifensine.
Synapse  •  1997  |  View Paper
6 At a high concentration (10 μm), the selective dopamine uptake inhibitor, nomifensine , completely blocked [3H]‐dopamine release evoked by amphetamine 0.3 μm and MPP+ 10 μm, attenuated responses to MPTP 50 μm and did not affect responses to 12 mm K+.
British journal of pharmacology  •  1995  |  View Paper
The release of DA induced by amphetamine could be effectively blocked by nomifensine and Lu 19-005, demonstrating that the in vivo movement of amines occurred via a transport carried-mediated mechanism.
European journal of pharmacology  •  1989  |  View Paper
Nomifensine , an inhibitor of neuronal uptake of dopamine prevented the release of [3H]dopamine induced by exposure to 10 microM amphetamine and antagonized the inhibitory effects of lower concentrations of amphetamine on the electrically evoked release of [3H]dopamine.
The Journal of pharmacology and experimental therapeutics  •  1983  |  View Paper
Nomifensine (1 microM) enhanced the DA releasing actions of PCP and other nonamphetamine stimulants, but antagonized the DA releasing action of amphetamine.
The Journal of pharmacology and experimental therapeutics  •  1982  |  View Paper
The dopamine carrier blocker nomifensine prevented the releasing action of amphetamine but not that of acetylcholine.
Neurochemistry International  •  1985  |  View Paper