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“Both early (30 min) and late (24 h) analgesic effects of cathinone were prevented by reserpine or p-chlorophenylalanine, which deplete catecholamines or serotonin, respectively, and by nomifensine , which prevents neuronal uptake of biogenic amines and amphetamines.”
“Conversely, DAT inhibitors, such as cocaine, mazindol, and nomifensine , when administered with AMPH , blocked the reduction in [(3)H]DA uptake and the redistribution of DAT immunofluorescence to the cytosol.”
Proceedings of the National Academy of Sciences of the United States of America • 2000 | View Paper
“Combination treatment with amphetamine and nomifensine produced waking activity greater than the sum of their individual activities alone while ameliorating the amphetamine-like RHS.”
“In rat synaptosomes, nomifensine reduced the potency of amphetamine to induce DA release approximately 270-fold, potentially explaining its action in ameliorating amphetamine-induced RHS.”
“6 At a high concentration (10 μm), the selective dopamine uptake inhibitor, nomifensine , completely blocked [3H]‐dopamine release evoked by amphetamine 0.3 μm and MPP+ 10 μm, attenuated responses to MPTP 50 μm and did not affect responses to 12 mm K+.”
British journal of pharmacology • 1995 | View Paper
“The release of DA induced by amphetamine could be effectively blocked by nomifensine and Lu 19-005, demonstrating that the in vivo movement of amines occurred via a transport carried-mediated mechanism.”
European journal of pharmacology • 1989 | View Paper
“ Nomifensine , an inhibitor of neuronal uptake of dopamine prevented the release of [3H]dopamine induced by exposure to 10 microM amphetamine and antagonized the inhibitory effects of lower concentrations of amphetamine on the electrically evoked release of [3H]dopamine.”
The Journal of pharmacology and experimental therapeutics • 1983 | View Paper
“ Nomifensine (1 microM) enhanced the DA releasing actions of PCP and other nonamphetamine stimulants, but antagonized the DA releasing action of amphetamine.”