Possible Interaction: Amphetamine and Nitric Oxide

“ NO donor and inhibitor blocked the amphetamine‐induced increase in striatal cAMP.NO donor modifies cAMP levels in both striatum and prefrontal cortex.”

“We previously demonstrated that NO inhibitors, similarly to the antipsychotic drugs, attenuate the disruptive effect of amphetamine or its analogue methylphenidate in the PPI response.”

“In the present study, we examined the involvement of NO in the neurotoxic effects of AMPH , to investigate the hypothesis that altered nitric oxide synthase (NOS) function was involved.”

“It appears that AMPH enhances release of ACH and neurotransmitter amino acids through increased NO synthesis and induces neurotoxicity via NO and also by NO‐independent LPO.”

“These results suggest that glutamatergic transmission and subsequent NMDA receptor activation and the production of nitric oxide play a critical role in the expression of the sensitized stereotyped behavioral response elicited by amphetamine or apomorphine.”

“ Amphetamine decreased choice of the large reinforcer in the No Cue group and increased it in the Cue group.”

“The present findings provide further evidence for an interaction at the behavioral level between NO and the DA-mediated effects of amphetamine and cocaine; moreover, they seem to indicate that both DA D1 and DA D2 receptor subtypes are under such influence.”

“Both NO generation and LPO products as well as release of ACH were increased in brain structures following four injections of amphetamine (AMPH).”

“Single injection of AMPH showed a more pronounced increase in NO and TBARS levels than after an equimolar concentration of sydnocarb.”