Possible Interaction: Amphetamine and Nifedipine

“The results showed that nifedipine potentiated amphetamine cytotoxicity in vitro, as follows: cell viability dropped by 65% (p>0.001), GSH by 80% (p>0.001), and LDH activity increased by 190% (p>0.001).”

“Calcium antagonists might interfere with neuronal changes induced by amphetamine, but at present it is difficult to explain the strong avoidance facilitation produced by combinations of nifedipine and amphetamine.”

“While ineffective alone, nifedipine strongly enhanced the shuttle-box avoidance facilitating action of amphetamine (1 and 2 mg/kg IP) in low performing CD-1 mice.”

“… nifedipine (5 mg/kg) shortly before each … the development of sensitized response to amphetamine as well as the stress-induced elevation of the densities of L-type Ca2+ channels in the hippocampus … densities of [3H]nitrendipine binding sites in the cortex and D1 dopamine receptors in the limbic forebrain.”

“Diltiazem and nifedipine blocked the amphetamine induced facilitation of FSA, while verapamil blocked both amphetamine as well as physostigmine induced facilitation of FSA.”

“ Nifedipine , 1 microM, failed to block either the Ca++-dependent release of [3H]DA or the inhibition of K+-evoked release by amphetamine.”

“ Amphetamine was capable of further suppressing the release of estradiol release under the presence of nifedipine.”