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Last Updated: 2 years ago

Possible Interaction: Amphetamine and Neuropeptide Y

Research Papers that Mention the Interaction

Amphetamine (AMPH), an appetite suppressant, alters expression levels of neuropeptide Y (NPY) and cocaine- and amphetamine-regulated transcript (CART) in the hypothalamus.
European Neuropsychopharmacology  •  2019  |  View Paper
Amphetamine is a releaser of dopamine stored in synaptic terminals, which can suppress appetite by changing the expression levels of neuropeptide Y (NPY) and proopiomelanocortin (POMC) in the hypothalamus.
British journal of pharmacology  •  2018  |  View Paper
An intracerebroventricular infusion of NPY antisense 60 min prior to AMPH treatment increased the levels of leptin, as well as the expression in LepRb, JAK2, and CART, whereas an infusion of STAT3 antisense decreased these levels and the expression of these parameters.
During the AMPH treatment, blood leptin levels and hypothalamic NPY expression decreased, with the largest reduction observed on Day 2.
Hormones and Behavior  •  2018  |  View Paper
Amphetamine (AMPH)-induced appetite suppression has been attributed to its inhibition of neuropeptide Y (NPY)-containing neurons in the hypothalamus.
Hormones and Behavior  •  2015  |  View Paper
Hypothalamic neuropeptides, including neuropeptide Y (NPY) and proopiomelanocortin (POMC), have been found to control the appetite‐suppressing effect of amphetamine (AMPH).
Genes, brain, and behavior  •  2014  |  View Paper
Appetite suppression induced by amphetamine has been attributed to its inhibition of neuropeptide Y (NPY) neurons and activation of pro‐opiomelanocortin (POMC) neurons in the hypothalamus.
British journal of pharmacology  •  2014  |  View Paper
BackgroundHypothalamic neuropeptide Y NPY ) and two immediate early genes, c-fos and c-jun, have been found to be involved in regulating the appetite-suppressing effect of amphetamine (AMPH).
Molecular Brain  •  2013  |  View Paper
Central inhibitions of NPY formation or Y1R activity modulated the anorectic response of AMPH and the reciprocal regulation of NPY and MC3R, revealing a crucial role of Y1R in this action.
Neuropharmacology  •  2012  |  View Paper
It has been reported that neuropeptide Y (NPY) contributes to the behavioral response of amphetamine (AMPH), a psychostimulant.
Journal of psychopharmacology  •  2011  |  View Paper
Although amphetamine (AMPH)-induced appetite suppression has been attributed to its inhibitory action on neuropeptide Y (NPY), an appetite neurotransmitter abundant in the brain, molecular mechanisms underlying this effect are not well known.
American journal of physiology. Endocrinology and metabolism  •  2007  |  View Paper
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