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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Amphetamine
drug:
Naltrexone
Research Papers that Mention the Interaction
“Pretreatment with naltrexone significantly attenuated the subjective effects of amphetamine (P < 0.05), and this effect was time-dependent with a reduction from the 3-hour time point.”
“The results provide preliminary evidence that naltrexone may reduce the reinforcing effects of amphetamine via modulation of the opioid system.”
Effects of Naltrexone on the Subjective Response to Amphetamine in Healthy Volunteers“However, in a chronic model, naltrexone significantly attenuated the dopamine release caused by reinstatement of amphetamine.”
“In healthy humans, naltrexone attenuated the subjective effects of amphetamine , confirming our previous results.”
“The opioid antagonist naltrexone has been shown to attenuate the subjective effects of amphetamine.”
“We hypothesized that naltrexone would diminish the striatal dopamine release induced by amphetamine , which is considered an important mechanism behind many of its stimulant properties.”
“Compared to placebo, the abstinence rate was increased significantly (p < 0.05) by naltrexone in one of two amfetamine studies , whereas there was no statistical difference in the only study reporting methamfetamine use.”
“Early-phase human studies suggested naltrexone reduced amphetamine use among dependent individuals.”
“ Naltrexone and bupropion, when administered alone in clinical trials, modestly reduce amphetamine use.”
“RationaleOpioid antagonists (e.g., naltrexone ) and positive modulators of γ-aminobutyric-acidA (GABAA) receptors (e.g., alprazolam) modestly attenuate the abuse-related effects of stimulants like amphetamine.”
“Both preclinical and clinical studies suggest that the opioid antagonist naltrexone NTX ) is effective in reducing the abuse liability of amphetamine , raising the question of whether similar positive findings would be obtained for cocaine.”
“Recent human laboratory studies have demonstrated that naltrexone modulates some of the reinforcing effects of amphetamine.”
“Co-administration of naltrexone may selectively enhance amphetamine potency to decrease cocaine choice without increasing amphetamine potency to produce general behavioral disruption.”
Maintenance on naltrexone+amphetamine decreases cocaine-vs.-food choice in male rhesus monkeys.“The unselective opioid receptor antagonist naltrexone NTX ) modulates amphetamine‐induced effects in both laboratory animals and humans.”
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